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IL-12 p70 Antibody (AHC7129) in Flow
EBioMedicine 2019 -
Fig. 1 Increased plasma levels of IL-12 and IL-6 correlate with increased non-classical CD16 bright CD14 neg monocytes as well as with increased activation of classical CD16 neg CD14 bright monocytes in patients with MDD and suicide behaviour. Plasma levels of (a) IL-12p70 and (b) IL-6 in patients with MDD (n=33) and healthy controls (n=20) as determined by ELISA. Significant differences between patients wi... View More
产品信息
AHC7129
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
A25C4B6
抗原
Recombinant human IL-12.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 5mg/mL BSA
内含物
0.5mg/mL sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2536290
产品详细信息
This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number A25C 4B6 1B3.
靶标信息
IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 20C2; CLMF p35; CLMF p40; cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL-12A; IL-12B; IL12, subunit p40; IL12A/B; IL12AB; IL35 subunit; ILN; Interleukin; interleukin 12, p35; interleukin 12, p40; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 alpha chain; interleukin-12 beta chain; Interleukin-12 p70; Interleukin-12 subunit alpha; Interleukin-12 subunit beta; MGC151228; MGC151232; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF1; NKSF2
基因别名: CLMF; CLMF2; IL-12A; IL-12B; IL12A; IL12B; IMD28; IMD29; NFSK; NKSF; NKSF1; NKSF2; P35
UniProt ID: (Human) P29459, (Human) P29460
Entrez Gene ID: (Human) 3592, (Human) 3593
cytokine activity
interleukin-12 receptor binding
protein binding
growth factor activity
interleukin-12 beta subunit binding
interleukin-27 binding
protein heterodimerization activity
cytokine receptor activity
interleukin-12 alpha subunit binding
identical protein binding
protein homodimerization activity
interleukin-23 receptor binding
transmembrane signal receptor
positive regulation of T cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
immune response
cell cycle arrest
response to virus
response to UV-B
cell migration
response to lipopolysaccharide
negative regulation of interleukin-17 production
positive regulation of interferon-gamma production
positive regulation of natural killer cell activation
positive regulation of mononuclear cell proliferation
positive regulation of smooth muscle cell apoptotic process
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of Stat4 protein
defense response to protozoan
positive regulation of T cell differentiation
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
negative regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
defense response to Gram-positive bacterium
positive regulation of NK T cell activation
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway
cellular response to virus
positive regulation of dendritic cell chemotaxis
positive regulation of defense response to virus by host
natural killer cell activation involved in immune response
positive regulation of T-helper 1 type immune response
negative regulation of inflammatory response to antigenic stimulus
positive regulation of activation of JAK2 kinase activity
cytokine-mediated signaling pathway
sensory perception of pain
sexual reproduction
natural killer cell activation
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell proliferation
positive regulation of tissue remodeling
regulation of cytokine biosynthetic process
T-helper 1 type immune response
T-helper cell differentiation
interferon-gamma biosynthetic process
positive regulation of activated T cell proliferation
positive regulation of NF-kappaB import into nucleus
regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of memory T cell differentiation
negative regulation of growth of symbiont in host
positive regulation of interferon-gamma biosynthetic process
positive regulation of osteoclast differentiation
positive regulation of inflammatory response
defense response to Gram-negative bacterium
positive regulation of NK T cell proliferation
defense response to virus
cellular response to interferon-gamma
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
