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IL-17 A/F Antibody (MA5-23748) in IHC
PLoS pathogens 2022 -
10.1371/journal.ppat.1010185.g004 Fig 4 IL-17-expressing cells infiltrate joint tissues during RRV disease. A) Confocal microscopy of immunofluorescent staining of optically cleared 150mum-thick vibratome sections of feet from mock-infected or RRV-infected IL-17 GFP mice, at 10 dpi. Scale bars = 50mum. Wholemount sections were stained for Type IV Collagen (red) and nuclei labelled with DAPI (blue). B) Immun... View More
产品信息
MA5-23748
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
50104
抗原
E. coli-derived recombinant mouse IL-17 Thr22-Ala158
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2607352
产品详细信息
In direct ELISAs, approximately 40% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; il 17; IL-17; IL-17F; ILN; Interleukin; Interleukin-17A; Interleukin-17F
基因别名: C87042; Ctla-8; Ctla8; IL-17; IL-17A; IL-17F; Il17; Il17a; Il17f
UniProt ID: (Mouse) Q62386, (Mouse) Q7TNI7
Entrez Gene ID: (Mouse) 16171, (Mouse) 257630
inflammatory response
positive regulation of necrotic cell death
positive regulation of interleukin-23 production
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to interleukin-1
cellular response to glucocorticoid stimulus
fibroblast activation
positive regulation of cytokine production involved in inflammatory response
proteoglycan metabolic process
negative regulation of angiogenesis
regulation of transforming growth factor beta receptor signaling pathway
cytokine biosynthetic process
lymphotoxin A biosynthetic process
regulation of interleukin-2 biosynthetic process
regulation of interleukin-6 biosynthetic process
regulation of interleukin-8 biosynthetic process
regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
cartilage development
