Invitrogen

IL-17AF Monoclonal Antibody (1402nAF), Functional Grade, eBioscience™

产品信息

16-9172-38

应用

建议稀释比

已发表文章

中和实验 (Neu)

Assay-Dependent

功能检测 (Functional)

Assay-Dependent

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

1402nAF

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

no preservative

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

AB_2866341

产品详细信息

Description: The 1402nAF monoclonal antibody reacts with mouse interleukin (IL)-17AF heterodimer. This antibody specifically reacts with this heterodimer and has no reactivity for IL-17A or IL-17F homodimers.

Applications Reported: This 1402nAF antibody has been reported for use as a neutralization antibody of IL-17AF biological activity.

Applications Tested: The Functional Grade purified format of the 1402nAF antibody has been tested for neutralization of IL-17AF biological activity.

Storage and handling: Use in a sterile environment.

Filtration: 0.2 µm post-manufacturing filtered.

Purity: Greater than 90%, as determined by SDS-PAGE.

Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.

Aggregation: Less than 10%, as determined by HPLC.

靶标信息

IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (Th17) cells, gamma-delta T cells and several subsets of innate lymphoid cells. Somewhat less appreciated, IL-17A and IL-17F subunits can also form the heterodimer, IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。