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IL-28B Antibody (PA5-47202) in Neu
Neutralization of IL-28B in HepG2 human hepatocellular carcinoma cell line. Samples were incubated in IL-28B polyclonal antibody (Product # PA5-47202). Recombinant Mouse IL‚28B/IFN‚λ3 reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Inhibition of EMCV activity elicited by Recombinant Mouse IL‚28B/IFN‚λ3 (400 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse I... View More
产品信息
PA5-47202
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse IL-28B/IFN-lambda3 Asp20-Val193
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606897
产品详细信息
In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human IL-28A is observed. In Western blots, approximately 35% cross-reactivity (reducing conditions) and approximately 10% cross-reactivity (non-reducing conditions) with recombinant mouse IL-28A is observed. This antibody neutralizes 100% of recombinant mouse IL-28A.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
IL-28B encodes a cytokine distantly related to type I interferons and the IL-10 family. IL-28B, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IFN-lambda 3; IFN-lambda-3; IL-28B; ILN; interferon alpha; Interferon lambda-3; Interferon lambda-4; Interleukin; interleukin 28; interleukin 28B; interleukin 28C; Interleukin-28B
基因别名: IFL-1; Ifnl3; IL-28B; Il28; Il28b; INF-alpha; INF-lambda
UniProt ID: (Mouse) Q8CGK6
Entrez Gene ID: (Mouse) 338374
