Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
IL-6 Antibody (PM626) in WB
Microbiology spectrum 2022 -
FIG 7 Interaction with E. coli O111:B4 lipopolysaccharide and immunomodulatory activity of PN5. (A) CD analysis of the binding structure of AMPs with lipopolysaccharide (LPS); (B) effect of PN5 (2, 4, and 8 muM) on LPS-induced TNF-alpha production. The concentrations of TNF-alpha in the culture supernatants were determined by ELISA. (C) Western blot of TNF-alpha, TLR4, and beta-actin expression. LPS-pretrea... View More
产品信息
PM626
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant mouse IL-6
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_223488
产品详细信息
PM626 targets IL-6 in ELISA, and WB applications and shows reactivity with mouse samples.
The PM626 immunogen is recombinant mouse IL-6.
PM626 detects IL-6 which has a predicted molecular weight of approximately 22 kDa.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).
靶标信息
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell hybridoma growth factor; H-IL-6; IL-6; ILN; Interleukin; Interleukin HP-1; Interleukin-6; Interleukin6; M-IL-6; R-IL-6
基因别名: Il-6; Il6
UniProt ID: (Mouse) P08505
Entrez Gene ID: (Mouse) 16193
neutrophil apoptotic process
myeloid cell homeostasis
hepatic immune response
positive regulation of acute inflammatory response
negative regulation of protein kinase activity
acute-phase response
inflammatory response
immune response
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of vascular endothelial growth factor production
positive regulation of gene expression
cell growth
cytokine-mediated signaling pathway
endocrine pancreas development
neuron projection development
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein import into nucleus, translocation
positive regulation of T cell proliferation
T cell activation
regulation of cell proliferation
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
defense response to protozoan
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of chemokine biosynthetic process
regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of nitric oxide biosynthetic process
cell redox homeostasis
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of gluconeogenesis
positive regulation of translation
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
muscle cell cellular homeostasis
negative regulation of hormone secretion
negative regulation of muscle organ development
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
defense response to virus
positive regulation of protein kinase B signaling
positive regulation of transmission of nerve impulse
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
T-helper 17 cell lineage commitment
negative regulation of neuron death
