Invitrogen

IL-6 Monoclonal Antibody (MP5 20F3)

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IL-6 Antibody (AMC0864) in Flow

Mouse IL-6 Antibody. Stimulated mouse splenocytes were stained with anti-mouse CD4 FITC.

IL-6 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

IL-6 Antibody — Figure 4 ATP-liposome treatment reduces inflammatory gene and protein expression following ischemia-reperfusion (IR) injury A : Differential expression of cytokines, chemokines, cell adhesion molecules, and nitric oxide (NO) synthase was assessed in sham-operated (sham) controls and in the ischemic retinas of ATP (ATP)-, phosphatidylcholine (PC)-liposome-, and PBS-treated animals 24 h after reperfusion. Gene expression was assessed using real-time PCR in sham-operated controls and experimental retinas following IR. For each gene, results are expressed as a percentage of corresponding value in the sham-operated eye of PBS-treated animals+-standard error of the mean after normalization to beta-actin (*p<0.05, six animals per group). B : Immunohistochemistry for the Il1b, Il6, Ccl2, and Cxcl10 protein accumulation in post-ischemic retinas of ATP-, PC-liposome-, and PBS-treated mice is consistent with increased levels of the transcripts at the level of corresponding proteins. Scale bar indicates 100 mum. {TM}

产品信息

AMC0864

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

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免疫组化 (IHC)

Assay-dependent

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流式细胞分析 (Flow)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

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中和实验 (Neu)

Assay-dependent

其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

MP5 20F3

抗原

Recombinant mouse IL-6.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

purified

保存液

PBS

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2536388

靶标信息

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Cell reports

Zeng J,Wang Y,Luo Z,Chang LC,Yoo JS,Yan H,Choi Y,Xie X,Deverman BE,Gradinaru V,Gupton SL,Zlokovic BV,Zhao Z,Jung JU

AMC0864 was used in Western Blot to promote recovery and repair after brain injury and may represent an attractive therapeutic target.

Tue Aug 29 00:00:00 UTC 2023

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Cell reports

Zeng J,Wang Y,Luo Z,Chang LC,Yoo JS,Yan H,Choi Y,Xie X,Deverman BE,Gradinaru V,Gupton SL,Zlokovic BV,Zhao Z,Jung JU

AMC0864 was used in Immunohistochemistry-immunofluorescence to study the role of TRIM9 in resolving NF-κB-dependent neuroinflammation to promote recovery and repair after brain injury, representing an attractive therapeutic target.

Tue Apr 09 00:00:00 UTC 2019

IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age.

Journal of immunology (Baltimore, Md. : 1950)

Raynor J,Karns R,Almanan M,Li KP,Divanovic S,Chougnet CA,Hildeman DA

AMC0864 was used in ELISA to examine the accumulation of CD25 low T regulatory cells in aged mice

Sat Aug 01 00:00:00 UTC 2015

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization.

BMC cancer

Jang JY,Lee JK,Jeon YK,Kim CW

Tue Sep 17 00:00:00 UTC 2013

Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury.

Molecular vision

Dvoriantchikova G,Barakat DJ,Hernandez E,Shestopalov VI,Ivanov D

Thu Sep 30 00:00:00 UTC 2010

Liposome-delivered ATP effectively protects the retina against ischemia-reperfusion injury.

Molecular vision

Dvoriantchikova G,Barakat DJ,Hernandez E,Shestopalov VI,Ivanov D

AMC0864 was used in immunohistochemistry to report the effect of ATP encapsulated in liposomes on the level of inflammation and neuronal death in the retina induced by ischemia reperfusion

Tue Dec 28 00:00:00 UTC 2010

Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences.

International immunology

Martin-Orozco E,Kobayashi H,Van Uden J,Nguyen MD,Kornbluth RS,Raz E

AMC0864 was used in blocking assay to demonstrate that immunostimulatory DNA up-regulates a distinct profile of cell surface molecules on macrophages and B cells in vitro and in vivo.