Invitrogen

IL-6 Receptor Monoclonal Antibody (B-R6)

IL-6 Receptor Antibody in Flow Cytometry (Flow)

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IL-6 Receptor Antibody (AHR0061) in Flow

Flow cytometry analysis using an IL-6 Receptor Monoclonal antibody, clone B-R6 (Product # AHR0061) in U266 cells.

IL-6 Receptor Antibody in Western Blot (WB)

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产品信息

AHR0061

应用

建议稀释比

已发表文章

免疫印迹 (WB)

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免疫组织化学（多聚甲醛固定） (IHC (PFA))

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免疫组化（冰冻） (IHC (F))

Assay-dependent

流式细胞分析 (Flow)

Assay-dependent

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酶联免疫吸附实验 (ELISA)

Assay-dependent

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免疫沉淀 (IP)

Assay-dependent

中和实验 (Neu)

Assay-dependent

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其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

B-R6

抗原

CHO cells transfected with cDNA corresponding to the gp80 IL-6 receptor gene.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

4.0 mg/mL

纯化类型

purified

保存液

PBS, pH 7.2

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

AB_2536348

产品详细信息

Specificity: Recognizes the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

Biological Activity: Inhibits IL-6 induced proliferation of XG-1 cells

靶标信息

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome.

Arthritis & rheumatology (Hoboken, N.J.)

Pringle S,Wang X,Verstappen GMPJ,Terpstra JH,Zhang CK,He A,Patel V,Jones RE,Baird DM,Spijkervet FKL,Vissink A,Bootsma H,Coppes RP,Kroese FGM

AHR0061 was used in Immunohistochemistry (PFA fixed) to investigate the role of salivary gland stem cells in hyposalivation in primary SS.

Tue Jan 01 00:00:00 UTC 2019

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.

Hepatology (Baltimore, Md.)

Blechacz BR,Smoot RL,Bronk SF,Werneburg NW,Sirica AE,Gores GJ

Published figure using IL-6 Receptor monoclonal antibody (Product # AHR0061) in Western Blot

Tue Dec 01 00:00:00 UTC 2009

Involvement of hepcidin in the anemia of multiple myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sharma S,Nemeth E,Chen YH,Goodnough J,Huston A,Roodman GD,Ganz T,Lichtenstein A

AHR0061 was used in blocking or activating experiment to investigate the role of hepcidin in the anemia of multiple myeloma

Sun Jun 01 00:00:00 UTC 2008

Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity.

Experimental cell research

Thyrell L,Arulampalam V,Hjortsberg L,Farnebo M,Grandér D,Pokrovskaja Tamm K

AHR0061 was used in blocking or activating experiment to establish that IFNalpha treatment results in reduced STAT3 activity in two myeloma cell lines, U266-1984 and U-1958

Thu Nov 15 00:00:00 UTC 2007

Retinoic acid inhibits IL-6-dependent but not constitutive STAT3 activation in Epstein-Barr virus-immortalized B lymphocytes.

International journal of oncology

Zancai P,Cariati R,Quaia M,Guidoboni M,Rizzo S,Boiocchi M,Dolcetti R

AHR0061 was used in flow cytometry to evaluate the effects of retinoic acid on IL-6 signaling in lymphoblastoid B-cell lines

Sun Aug 01 00:00:00 UTC 2004

Interleukin-6 enhances whereas tumor necrosis factor alpha and interferons inhibit integrin expression and adhesion of human mast cells to extracellular matrix proteins.

The Journal of investigative dermatology

Schoeler D,Grützkau A,Henz BM,Küchler J,Krüger-Krasagakis S

AHR0061 was used in flow cytometry to assess the effects of cytokines on integrin expression and mast cell adhesion.

Thu May 01 00:00:00 UTC 2003

Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts.

The Journal of biological chemistry

Vermes C,Jacobs JJ,Zhang J,Firneisz G,Roebuck KA,Glant TT

Fri May 10 00:00:00 UTC 2002

Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line.

AIDS (London, England)

Gage JR,Breen EC,Echeverri A,Magpantay L,Kishimoto T,Miles S,Martínez-Maza O

AHR0061 was used in ELISA to study human herpesvirus 8 interleukin 6.

Fri Oct 01 00:00:00 UTC 1999

Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Bank U,Reinhold D,Schneemilch C,Kunz D,Synowitz HJ,Ansorge S

AHR0061 was used in flow cytometry to examine the role of role of neutrophil-derived serine proteases in traumatic brain injuries.

Mon Nov 01 00:00:00 UTC 1999

生物信息学

蛋白别名: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor subunit alpha; IL-6R 1; ILN; Interleukin; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991

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基因别名: CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6R; IL6RA; IL6RQ

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UniProt ID: (Human) P08887

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Entrez Gene ID: (Human) 3570

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功能

ciliary neurotrophic factor receptor activity interleukin-6 receptor activity interleukin-6 receptor binding protein binding enzyme binding interleukin-6 binding protein homodimerization activity ciliary neurotrophic factor binding transmembrane signal receptor

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