Invitrogen

IL21R Polyclonal Antibody

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IL21R Antibody (PA1-41412) in WB

Western blot analysis of IL21R in 30 µg Raji cell lysate. Samples were incubated in IL21R polyclonal antibody (Product # PA1-41412.

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产品信息

PA1-41412

应用

建议稀释比

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免疫印迹 (WB)

0.5-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptides corresponding to residues 65-80 and 505-521 of human IL-21R.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein G

保存液

PBS with 0.2% gelatin

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2280184

产品详细信息

This antibody is predicted to react with mouse samples based on sequence homology.

Suggested positive control: Raji whole cell lysate, NIH-3T3 whole cell lysate.

靶标信息

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.

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