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产品信息
H00058985-M03
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG3, kappa
分类
Monoclonal
类型
Antibody
克隆号
6B5
抗原
IL22RA1 (AAH29273, 19 a.a. approximately 574 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: EDPSDLLQHV KFQSSNFENI LTWDSGPEGT PDTVYSIEYK TYGERDWVAK KGCQRITRKS CNLTVETGNL TELYYARVTA VSAGGRSATK MTDRFSSLQH TTLKPPDVTC ISKVRSIQMI VHPTPTPIRA GDGHRLTLED IFHDLFYHLE LQVNRTYQMH LGGKQREYEF FGLTPDTEFL GTIMICVPTW AKESAPYMCR VKTLPDRTWT YSFSGAFLFS MGFLVAVLCY LSYRYVTKPP APPNSLNVQR VLTFQPLRFI QEHVLIPVFD LSGPSSLAQP VQYSQIRVSG PREPAGAPQR HSLSEITYLG QPDISILQPS NVPPPQILSP LSYAPNAAPE VGPPSYAPQV TPEAQFPFYA PQAISKVQPS SYAPQATPDS WPPSYGVCME GSGKDSPTGT LSSPKHLRPK GQLQKEPPAG SCMLGGLSLQ EVTSLAMEES QEAKSLHQPL GICTDRTSDP NVLHSGEEGT PQYLKGQLPL LSSVQIEGHP MSLPLQPPSR PCSPSDQGPS PWGLLESLVC PKDEAKSPAP ETSDLEQPTE LDSLFRGLAL TVQWES
靶标信息
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CRF2-9; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; Interleukin-22 receptor subunit alpha-1; ZcytoR11
基因别名: CRF2-9; IL22R; IL22R1; IL22RA1
UniProt ID: (Human) Q8N6P7
Entrez Gene ID: (Human) 58985
