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MA5-17100 targets INCENP in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17100 immunogen is purified recombinant fragment of human INCENP (amino acids: 369-583) expressed in E. Coli.
MA5-17100 detects INCENP which has a predicted molecular weight of approximately 105.4kDa.
Chromosomal passenger proteins are members of a group of proteins that move from centromeres to the spindle midzone during mitosis. INCENP (Inner Centromere Protein) is a chromosomal passenger protein with an essential role in mitosis and meiosis. It is a complex highly basic multidomain protein that is dynamically translocated from metaphase chromosomes to the spindle midzone during or just prior to anaphase. Some INCENP transfers to the equatorial cortex before formation of the cleavage furrow. Ultimately, it is discarded in the midbody at the completion of cytokinesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger protein; Inner centromere protein; inner centromere protein antigens 135/155kDa; inner centromere protein INCENP
基因别名: INCENP
UniProt ID: (Human) Q9NQS7
Entrez Gene ID: (Human) 3619