Invitrogen

ING4 Polyclonal Antibody

ING4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ING4 Antibody (PA5-111452) in IHC (P)

Immunohistochemical analysis of ING4 in human pancreas using ING4 Polyclonal Antibody (Product # PA5-111452) shows moderate nuclear positivity in exocrine glandular cells and additional cytoplasmic staining in islets of Langerhans.

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产品信息

PA5-111452

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:5,000-1:10,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Protein corresonding to Human ING4

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2856862

产品详细信息

Immunogen sequence: EKQIESSDYD SSSSKGKKKG RTQKEKKAAR ARSKGKNSDE EAPKTAQKKL KLVRTSPEYG MPSVTFGSVH

靶标信息

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.

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