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INHBB Antibody (PA5-28814) in IHC (P)
INHBB Polyclonal Antibody detects Inhibin beta B protein at cytoplasm on human normal kidney by immunohistochemical analysis. Sample: Paraffin-embedded human normal kidney. INHBB Polyclonal Antibody (Product # PA5-28814) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-28814
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 343 and 407 of Human Inhibin beta B
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546290
产品详细信息
Recommended positive controls: A431, H1299.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Chicken (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activin AB beta polypeptide; Activin beta-B chain; Inhibin beta B chain; inhibin, beta B; Inhibin, beta-2
基因别名: INHBB
UniProt ID: (Human) P09529
Entrez Gene ID: (Human) 3625
ovarian follicle development
defense response
cellular response to starvation
response to mechanical stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
cellular response to insulin stimulus
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
cellular response to leptin stimulus
fat cell differentiation
negative regulation of insulin secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
negative regulation of hepatocyte growth factor biosynthetic process
cell development
oocyte development
positive regulation of ovulation
SMAD protein signal transduction
positive regulation of apoptotic signaling pathway
