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INO80 Antibody (PA5-113532) in ICC/IF
Immunocytochemichal analysis of INO80 in Hela cells using a Polyclonal antibody (Product # PA5-113532) at a dilution of 1:100. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were also counter-stained with DAPI.
产品信息
PA5-113532
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Chromatin-remodeling ATPase INO80 protein (1365-1495AA)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2868265
靶标信息
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chromatin-remodeling ATPase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80 complex subunit A; INO80 homolog; putative DNA helicase INO80 complex homolog 1
基因别名: hINO80; INO80; INO80A; INOC1; KIAA1259
UniProt ID: (Human) Q9ULG1
Entrez Gene ID: (Human) 54617
mitotic sister chromatid segregation
double-strand break repair via homologous recombination
double-strand break repair
chromatin remodeling
transcription, DNA-templated
positive regulation of nuclear cell cycle DNA replication
positive regulation of cell growth
DNA duplex unwinding
cellular response to UV
positive regulation of transcription from RNA polymerase II promoter
spindle assembly
cell division
UV-damage excision repair
cellular response to ionizing radiation
regulation of G1/S transition of mitotic cell cycle
