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产品信息
PA1-16988
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region between residues 1-100 of human Insig1
偶联物
形式
Liquid
浓度
1.02 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 30% glycerol
内含物
0.1% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2126686
产品详细信息
This antibody does not cross-react with Insig2.
Suggested positive control: HepG2 lysate, antigen standard for INSIG1 (transient overexpression lysate).
靶标信息
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: growth response protein (CL-6); Immediate-early protein CL-6; INSIG-1; INSIG-1 membrane protein; Insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405
基因别名: CL-6; CL6; INSIG1
UniProt ID: (Human) O15503, (Rat) Q08755
Entrez Gene ID: (Human) 3638, (Rat) 64194
triglyceride metabolic process
cholesterol biosynthetic process
metabolic process
cell proliferation
negative regulation of steroid biosynthetic process
SREBP signaling pathway
inner ear morphogenesis
middle ear morphogenesis
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
palate development
cranial suture morphogenesis
negative regulation of cargo loading into COPII-coated vesicle
response to sterol depletion
cholesterol metabolic process
sterol biosynthetic process
response to estradiol
cellular response to insulin stimulus
response to lipid
response to peptide hormone
response to fatty acid
