Invitrogen

INSR Monoclonal Antibody (18-44)

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INSR Antibody (MA1-10865) in WB

Cell communication and signaling : CCS 2021 - Fig. 7 Effect of total calystegines on collapsed insulin signalling pathway in HI/HG HepG2 cells. a Quantitative analysis of insulin signalling-related proteins expression using western blot. b Representative blots images of insulin signalling-related proteins profiling. c Relative genes expression of key insulin signalling regulators. Representative data from three independent experiments are shown +- SD (... View More

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产品信息

MA1-10865

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-10 µg/mL

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酶联免疫吸附实验 (ELISA)

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免疫沉淀 (IP)

1-10 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

18-44

抗原

human placental insulin receptor.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.41 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_1075408

产品详细信息

MA1-10865 detects Insulin Receptor from human samples. Low cross-reactivity with bovine and rabbit samples.

MA1-10865 has been successfully used in Western blot and immunoprecipitation applications.

The MA1-10865 immunogen is human placental insulin receptor.

靶标信息

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance.

International journal of molecular sciences

Scarpa ES,Giordani C,Antonelli A,Petrelli M,Balercia G,Silvetti F,Pieroni A,Sabbatinelli J,Rippo MR,Olivieri F,Matacchione G

MA1-10865 was used in Western Blot to investigate, in in vitro models of insulin resistance, the ability of the flavanones naringenin and hesperetin, used alone and in combination with the anti-inflammatory natural molecules curcumin, polydatin, and quercetin, to counteract the insulin resistance and pro-inflammatory molecular mechanisms that are involved in T2DM development.

Sat Apr 29 00:00:00 UTC 2023

Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway.

Cell communication and signaling : CCS

Kowalczuk A,Bourebaba N,Kornicka-Garbowska K,Turlej E,Marycz K,Bourebaba L

MA1-10865 was used in Western Blot to demonstrate that calystegines from Hyoscyamus albus provide cytoprotection to the HepG2 cells against insulin/glucose induced insulin resistance and apoptosis due to the regulation of SIRT1/Foxo1/G6PC/mTOR and NF-κB/JNK/TLR4 signaling pathways.

Tue May 25 00:00:00 UTC 2021

Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway.

Cell communication and signaling : CCS

Kowalczuk A,Bourebaba N,Kornicka-Garbowska K,Turlej E,Marycz K,Bourebaba L

Tue May 25 00:00:00 UTC 2021

The beta secretase BACE1 regulates the expression of insulin receptor in the liver.

Nature communications

Meakin PJ,Mezzapesa A,Benabou E,Haas ME,Bonardo B,Grino M,Brunel JM,Desbois-Mouthon C,Biddinger SB,Govers R,Ashford MLJ,Peiretti F

MA1-10865 was used in an ELISA assay to show that plasma levels of cleaved IR reflect IR isoform A expression levels in liver tumors, which prompts us to propose that the measurement of circulating cleaved IR may assist hepatic cancer detection and management.

Tue Apr 03 00:00:00 UTC 2018

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

Cancer research

Burtrum D,Zhu Z,Lu D,Anderson DM,Prewett M,Pereira DS,Bassi R,Abdullah R,Hooper AT,Koo H,Jimenez X,Johnson D,Apblett R,Kussie P,Bohlen P,Witte L,Hicklin DJ,Ludwig DL

MA1-10865 was used in immunoprecipitation to investigate the effectiveness of a humanized monoclonal insulin-like growth factor I receptor antibody against human tumor growth

Mon Dec 15 00:00:00 UTC 2003

生物信息学

蛋白别名: CD 220; CD220; CD220 antigen; CD220 beta; CD221; HHF 5; IGF-I receptor; Insulin receptor; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR-1; IR1

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基因别名: CD220; HHF5; INSR

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UniProt ID: (Human) P06213

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Entrez Gene ID: (Human) 3643

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功能