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INTU Antibody (PA5-35900) in ICC/IF
INTU Polyclonal Antibody detects INTU protein at cytoplasm by immunofluorescent analysis. Sample: SKNSH cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: INTU protein stained by INTU Polyclonal Antibody (Product # PA5-35900) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-35900
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 693 and 942 of INTU
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2553210
产品详细信息
Recommended positive controls: Mouse brain.
Predicted reactivity: Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of inturned; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned
基因别名: 9230116I04Rik; 9430087H23Rik; INT; INTU; KIAA1284; mKIAA1284; PDZD6; PDZK6
UniProt ID: (Human) Q9ULD6, (Mouse) Q059U7
Entrez Gene ID: (Human) 27152, (Mouse) 380614
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
spinal cord dorsal/ventral patterning
neural tube development
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
cilium assembly
embryonic digit morphogenesis
positive regulation of smoothened signaling pathway
negative regulation of cell division
limb development
motile primary cilium assembly
multicellular organism development
cell projection organization
cilium morphogenesis
