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产品信息
PA5-57785
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642750
产品详细信息
Immunogen sequence: NDNGPVSILK HQSNQKTGVI VQQRYKDVNV YVNPKKLTVI KAKEQLKLLE VLVGIIHQTK WSWRRTGKQG DGERLVVHGL LPGGSAMKSG QVLIGDV
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.
靶标信息
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of inturned; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned
基因别名: INT; INTU; KIAA1284; PDZD6; PDZK6
UniProt ID: (Human) Q9ULD6
Entrez Gene ID: (Human) 27152
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
spinal cord dorsal/ventral patterning
neural tube development
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
cilium assembly
embryonic digit morphogenesis
positive regulation of smoothened signaling pathway
negative regulation of cell division
limb development
motile primary cilium assembly
