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Invitrogen
IP3 Receptor 1 Recombinant Rabbit Monoclonal Antibody (ARC1007)
FIGURE: 1 / 5
IP3 Receptor 1 Antibody (MA5-35516) in IHC (P)
Immunohistochemistry analysis of IP3 Receptor 1 in paraffin-embedded mouse brain. Samples were incubated with IP3 Receptor 1 Monoclonal antibody (Product # MA5-35516) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35516
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1007
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 2200-2300 of human IP3R (Q14643)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849416
Product Specific Information
Immunogen sequence: HTAQIEIVRL DRTMEQIVFP VPSICEFLTK ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF NLAVLMNLLV A
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
Gene Aliases: D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; InsP3R1; Ip3r; IP3R1; Itpr-1; Itpr1; opt; P400; Pcd6; Pcp-1; Pcp1
UniProt ID: (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Mouse) 16438, (Rat) 25262
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
protein binding
protein C-terminus binding
calcium-release channel activity
calcium channel inhibitor activity
protein phosphatase binding
protein complex binding
phosphatidylinositol binding
ligand-gated ion channel
response to hypoxia
transport
ion transport
calcium ion transport
apoptotic process
positive regulation of cytosolic calcium ion concentration
post-embryonic development
endoplasmic reticulum calcium ion homeostasis
inositol phosphate-mediated signaling
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
positive regulation of calcium ion transport
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
cellular response to cAMP
negative regulation of neuron death
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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