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IPO5 Antibody (PA5-78567) in IHC (P)
IPO5 Polyclonal Antibody detects IPO5 protein at nucleus on rat hind brain by immunohistochemical analysis. Sample: Paraffin-embedded rat hind brain. IPO5 Polyclonal Antibody (Product # PA5-78567) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-78567
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human IPO5. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.58 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2735960
产品详细信息
Predicted Reactivity: Human (100%), Xenopus laevis (96%), Pig (98%), Chimpanzee (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Imp5; importin 5; importin beta-3 subunit; Importin subunit beta-3; Importin-5; IPO 5; karyopherin (importin) beta 3; Karyopherin beta 3; Karyopherin beta-3; MGC2068; RAN binding protein 5; Ran-binding protein 5; Ran_GTP binding protein 5; RanBP 5; RanBP5
基因别名: 1110011C18Rik; 5730478E03Rik; AA409333; C76941; IMB3; imp5; IPO5; KPNB3; Pse1; RANBP5
UniProt ID: (Human) O00410, (Mouse) Q8BKC5
Entrez Gene ID: (Human) 3843, (Rat) 306182, (Mouse) 70572
protein import into nucleus, docking
protein import into nucleus, translocation
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
viral process
negative regulation of GTPase activity
positive regulation of protein import into nucleus
cellular response to amino acid stimulus
intracellular protein transport
transport
protein transport
