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Immunogen sequence: AVTLQRAALK FLAKCRKKKK LFAPWRGLQE LTDARRVELK KRVDDYVRRH LGSPMSDVVS RELHAQAQER LQHYFMGRAL EERAQQHREA LIAQISTNVE QLMK
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: IQ calmodulin-binding motif-containing protein 1; nephrocystin 5; Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein; PIQ
基因别名: IQCB1; KIAA0036; NPHP5; OK/SW-cl.85; PIQ; SLSN5
UniProt ID: (Human) Q15051
Entrez Gene ID: (Human) 9657