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产品信息
PA5-58268
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642771
产品详细信息
Immunogen sequence: GSLKRQSAYE RSLGGQQGSP KHGPHSGAPK SLPREEPELR PRPPRPLDSH LAINGSANRQ SKSESDYSDG DNDSINSTSN S
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
靶标信息
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.
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生物信息学
蛋白别名: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; BRAG2; brefeldin A-resistant ARF-GEF2; Brefeldin-resistant Arf-GEF 2 protein; IQ motif and SEC7 domain-containing protein 1
基因别名: ARF-GEP100; ARFGEP100; BRAG2; GEP100; IQSEC1; KIAA0763
UniProt ID: (Human) Q6DN90
Entrez Gene ID: (Human) 9922
