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产品信息
MA5-24849
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide of human IRF1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography, Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2717287
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Purity is > 95% by SDS-PAGE.
靶标信息
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. Diseases associated with IRF1 include gastric cancer, somatic and lung cancer.
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生物信息学
蛋白别名: Interferon regulatory factor 1; interferon regulatory factor 1 isoform +I9; interferon regulatory factor 1 isoform d78; interferon regulatory factor 1 isoform delta4; interferon regulatory factor 1 isoform delta7; IRF-1
基因别名: AU020929; IRF-1; IRF1; MAR
UniProt ID: (Human) P10914, (Mouse) P15314, (Rat) P23570
Entrez Gene ID: (Human) 3659, (Mouse) 16362, (Rat) 24508
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
regulatory region DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
regulation of adaptive immune response
transcription from RNA polymerase II promoter
apoptotic process
cell cycle arrest
blood coagulation
negative regulation of cell proliferation
positive regulation of type I interferon production
positive regulation of interferon-beta production
regulation of MyD88-dependent toll-like receptor signaling pathway
cellular response to interferon-beta
CD8-positive, alpha-beta T cell differentiation
positive regulation of interleukin-12 biosynthetic process
regulation of innate immune response
negative regulation of regulatory T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of cell cycle
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
cellular response to mechanical stimulus
regulation of CD8-positive, alpha-beta T cell proliferation
immune system process
transcription, DNA-templated
regulation of transcription, DNA-templated
I-kappaB kinase/NF-kappaB signaling
regulation of gene expression
positive regulation of cell death
positive regulation of natural killer cell differentiation
negative regulation of tyrosine phosphorylation of Stat1 protein
innate immune response
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
response to growth hormone
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to peptide hormone stimulus
female pregnancy
response to heat
regulation of cell proliferation
cellular response to retinoic acid
cellular response to dsRNA
