Invitrogen

IRF6 Polyclonal Antibody

IRF6 Antibody in Immunocytochemistry (ICC/IF)

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IRF6 Antibody (PA5-84583) in ICC/IF

Immunofluorecent analysis of IRF6 in human cell line HaCaT using IRF6 Polyclonal Antibody (Product # PA5-84583). Staining shows localization to nucleus, cytosol and cell junctions.

IRF6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

IRF6 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of IRF6 demonstrates antibody specificity. Immunohistochemical analysis of IRF6 using anti-IRF6 Polyclonal Antibody (Product #PA5-84583), shows significant staining of IRF6 in breast and shows minimal or weak staining in pancreas tissues. The relative expression levels of IRF6 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-84583

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human IRF6. Recombinant protein control fragment (Product #RP-103781).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2791734

产品详细信息

Immunogen sequence: KSREFNLMYD GTKEVPMNPV KIYQVCDIPQ PQGSIINPGS TGSAPWDEKD NDVDEE

靶标信息

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer.

Bioengineered

Tan L,Qu W,Wu D,Liu M,Ai Q,Hu H,Wang Q,Chen W,Zhou H

PA5-84583 was used in Immunocytochemistry-immunoflourescence to suggest that IRF6 may enhance chemotherapeutic sensitivity of cisplatin mediated by affecting cell proliferation, migration and invasion along with apoptosis through regulating E-cadherin and Ki67, while the identified molecular mechanisms remain to be further explored.