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产品信息
IRF8M-FITC
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 350-400 on mouse Interferon Regulatory Factor 8 protein.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ICSBP; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; transcription factor ICSBP
基因别名: AI893568; ICSBP; Icsbp1; IRF-8; Irf8; Myls
UniProt ID: (Mouse) P23611
Entrez Gene ID: (Rat) 292060, (Mouse) 15900
phagocytosis
immune response
response to bacterium
myeloid cell differentiation
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
defense response to bacterium
defense response to protozoan
negative regulation of growth of symbiont in host
positive regulation of transcription, DNA-templated
positive regulation of transcription initiation from RNA polymerase II promoter
cellular response to lipopolysaccharide
