Invitrogen

IRS2 Polyclonal Antibody

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IRS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IRS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IRS2 Antibody (PA5-119570) in IHC (P)

Immunohistochemistry of IRS2 in paraffin-embedded mouse muscle. Sample was treated for antigen retrieval with Citrate buffer (pH 6.0, 15 min) and incubated with polyclonal IRS2 antibody (Product # PA5-119570) at a dilution of 1:100.

IRS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IRS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of IRS2 in paraffin-embedded mouse muscle. Sample was treated for antigen retrieval with Citrate buffer (pH 6.0, 15 min) and incubated with polyclonal IRS2 antibody (Product # PA5-119570) at a dilution of 1:100.

产品信息

PA5-119570

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

-

免疫组化（石蜡） (IHC (P))

Assay-dependent

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the C-terminus region of human IRS2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.15 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2913143

产品详细信息

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

靶标信息

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 4PS; Insulin receptor substrate 2; IRS-2

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基因别名: IRS-2; IRS2

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UniProt ID: (Human) Q9Y4H2, (Mouse) P81122

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Entrez Gene ID: (Human) 8660, (Mouse) 384783

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signal transducer activity Ras guanyl-nucleotide exchange factor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein phosphatase binding protein domain specific binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 14-3-3 protein binding

参与通路

positive regulation of mesenchymal cell proliferation negative regulation of B cell apoptotic process signal transduction brain development cell proliferation positive regulation of cell proliferation insulin receptor signaling pathway response to glucose negative regulation of plasma membrane long-chain fatty acid transport positive regulation of glucose metabolic process regulation of lipid metabolic process positive regulation of cell migration mammary gland development positive regulation of B cell proliferation positive regulation of fatty acid beta-oxidation positive regulation of insulin secretion cellular response to insulin stimulus negative regulation of kinase activity positive regulation of glycogen biosynthetic process positive regulation of glucose import MAPK cascade glucose metabolic process regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol-3-phosphate biosynthetic process positive regulation of GTPase activity phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling lipid homeostasis cellular response to glucose stimulus