Invitrogen

IRS2 Polyclonal Antibody

抗体检测数据 (1)

IRS2 Antibody in Immunocytochemistry (ICC/IF)

IRS2 Antibody in Immunocytochemistry (ICC/IF)

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IRS2 Antibody (PA5-65889) in ICC/IF

Immunofluorescent staining of IRS2 in human cell line HeLa shows localization to cytosol. Samples were probed using an IRS2 Polyclonal Antibody (Product # PA5-65889).

IRS2 Antibody in Immunocytochemistry (ICC/IF)

Product Image Gallery

IRS2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent staining of IRS2 in human cell line HeLa shows localization to cytosol. Samples were probed using an IRS2 Polyclonal Antibody (Product # PA5-65889).

产品信息

PA5-65889

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Human IRS2. Recombinant protein control fragment (Product #RP-106563).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2665252

产品详细信息

Immunogen sequence: ELYRLPPASAV ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA ATPPQPIAAP PKPEAARVAS PTSGVKRLSL MEQVSGVEAF LQAS

Highest antigen sequence identity to the following orthologs - mouse 85%, rat 84%.

靶标信息

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Insulin receptor substrate 2; IRS-2

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基因别名: IRS-2; IRS2

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UniProt ID: (Human) Q9Y4H2

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Entrez Gene ID: (Human) 8660

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signal transducer activity Ras guanyl-nucleotide exchange factor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein phosphatase binding protein domain specific binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 14-3-3 protein binding

参与通路

MAPK cascade positive regulation of mesenchymal cell proliferation negative regulation of B cell apoptotic process glucose metabolic process signal transduction brain development cell proliferation positive regulation of cell proliferation insulin receptor signaling pathway response to glucose negative regulation of plasma membrane long-chain fatty acid transport positive regulation of glucose metabolic process regulation of phosphatidylinositol 3-kinase signaling regulation of lipid metabolic process positive regulation of cell migration mammary gland development positive regulation of B cell proliferation positive regulation of fatty acid beta-oxidation positive regulation of insulin secretion cellular response to insulin stimulus negative regulation of kinase activity phosphatidylinositol-3-phosphate biosynthetic process positive regulation of GTPase activity positive regulation of glycogen biosynthetic process positive regulation of glucose import phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling lipid homeostasis cellular response to glucose stimulus