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IST1 Antibody (PA5-106294) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded IST1 in mouse spleen tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with IST1 polyclonal antibody (Product # PA5-106294) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-106294
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human IST1(Accession P53990), corresponding to amino acid residues P246-Q296.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853971
产品详细信息
Antibody detects endogenous levels of total IST1.
靶标信息
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Charged multivesicular body protein 8; CHMP8; hIST1; increased sodium tolerance 1 homolog; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; MGC117220; overexpressed in lung cancer 1; pm28; Putative MAPK-activating protein PM28
基因别名: 2400003C14Rik; AW536298; IST1; KIAA0174; mKIAA0174; OLC1
UniProt ID: (Human) P53990, (Mouse) Q9CX00
Entrez Gene ID: (Human) 9798, (Mouse) 71955
cytokinesis
positive regulation of defense response to virus by host
protein localization
abscission
protein transport
viral release from host cell
multivesicular body assembly
establishment of protein localization
positive regulation of proteolysis
viral capsid secondary envelopment
positive regulation of collateral sprouting
cell division
cell-cell adhesion
mitophagy in response to mitochondrial depolarization
xenophagy
ESCRT III complex disassembly
cell cycle
