Invitrogen

ISYNA1 Polyclonal Antibody

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ISYNA1 Antibody (PA5-44105) in WB

Western blot analysis of human adult placenta cells using an anti-ISYNA1 polyclonal antibody (Product # PA5-44105).

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产品信息

PA5-44105

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the N-terminal of human ISYNA1 (aa 161-210).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2577108

产品详细信息

Peptide sequence: LQEQLWPHME ALRPRPSVYI PEFIAANQSA RADNLIPGSR AQQLEQIRRD

Sequence homology: Cow: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 86%; Rat: 86%; Yeast: 92%

靶标信息

Myoinositol, the most common naturally occurring form of inositol, is a component of plasma membrane phospholipids and functions as a cell signaling molecule. ISYNA1 (EC 5.5.1.4), or IPS, is a rate-limiting enzyme that catalyzes the de novo synthesis of myoinositol 1-phosphate from glucose 6-phosphate. Myoinositol, the most common naturally occurring form of inositol, is a component of plasma membrane phospholipids and functions as a cell signaling molecule. ISYNA1 (EC 5.5.1.4), or IPS, is a rate-limiting enzyme that catalyzes the de novo synthesis of myoinositol 1-phosphate from glucose 6-phosphate (Seelan et al., 2004 ).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.

Cell death & disease

Cui Z,Mu C,Wu Z,Pan S,Cheng Z,Zhang ZQ,Zhao J,Xu C

PA5-44105 was used in Western Blotting to show that elevated SLC5A3 promotes NSCLC cell growth possibly by maintaining myo-inositol contents and promoting Akt-mTOR activation.

Mon Jun 27 00:00:00 UTC 2022

Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase.

The Journal of biological chemistry

Lazcano P,Schmidtke MW,Onu CJ,Greenberg ML

PA5-44105 was used in Western Blotting to show that activation of AMPK by glucose deprivation or by treatment with the mood-stabilizing drugs valproate (VPA) or lithium recapitulated IP6K1 nuclear translocation and decreased MIPS expression.

Thu Sep 01 00:00:00 UTC 2022

Regulated inositol synthesis is critical for balanced metabolism and development in Drosophila melanogaster.

Biology open

Rivera MJ,Contreras A,Nguyen LT,Eldon ED,Klig LS

Published figure using ISYNA1 polyclonal antibody (Product # PA5-44105) in Western Blot

Fri Oct 15 00:00:00 UTC 2021

生物信息学

蛋白别名: hINO1; Inositol-3-phosphate synthase 1; IPS 1; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase; Myo-inositol 1-phosphate synthase A1; testis secretory sperm-binding protein Li 200a

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基因别名: INO1; INOS; IPS; IPS 1; IPS-1; ISYNA1

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UniProt ID: (Human) Q9NPH2

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Entrez Gene ID: (Human) 51477

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功能

inositol-3-phosphate synthase activity protein binding isomerase metabolite interconversion enzyme

参与通路

inositol biosynthetic process phospholipid biosynthetic process inositol phosphate metabolic process