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产品信息
PA5-56425
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642827
产品详细信息
Immunogen sequence: PDKPFLRKAC SPSNIPAVII TDMGTQEDGA LEETQGSPRG NLPLRKLSSS SASSTGFSSS YEDSEEDISS DPE
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 82%.
靶标信息
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.
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生物信息学
蛋白别名: Inositol 1,4,5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3K B; proliferation-inducing protein 37
基因别名: IP3-3KB; IP3K; IP3K-B; IP3KB; ITPKB; PIG37
UniProt ID: (Human) P27987
Entrez Gene ID: (Human) 3707
MAPK cascade
regulation of protein phosphorylation
myeloid cell homeostasis
signal transduction
cell surface receptor signaling pathway
inositol trisphosphate metabolic process
negative regulation of neutrophil apoptotic process
common myeloid progenitor cell proliferation
inositol phosphate metabolic process
positive thymic T cell selection
negative regulation of myeloid cell differentiation
positive regulation of Ras protein signal transduction
positive regulation of alpha-beta T cell differentiation
cellular response to calcium ion
