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产品信息
PA5-88758
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3 (NP_0022152)
偶联物
形式
Liquid
浓度
2.83 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805108
产品详细信息
Immunogen sequence: EGSEAYQRCE SGGFLSKLIQ HTKDLMESEE KLCIKVLRTL QQMLLKKTKY GDRGNQLRKM LLQNYLQNRK STSRGDLPDP IGTGLDPDWS AIAATQCRLD KEGATKLVCD LITSTKNEKI FQESIGLAIH LLDGGNTEIQ KSFHNLMMSD KKSERFFKVL HDRMKRAQQE TKSTVAVNMN DLGSQPHEDR EPVDPTTKGR VASFSIPGSS SRYSLGPSLR RGHEVSERVQ SSEMGTSVLI M; Positive Samples: HeLa, LO2, HepG2; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
靶标信息
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor, type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
基因别名: IP3R; IP3R3; Itpr-3; ITPR3
UniProt ID: (Human) Q14573, (Mouse) P70227
Entrez Gene ID: (Human) 3710, (Mouse) 16440
inositol hexakisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium ion binding
protein binding
calcium-release channel activity
phosphatidylinositol binding
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
ion channel activity
calcium channel activity
ligand-gated ion channel
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
memory
platelet activation
inositol phosphate-mediated signaling
regulation of insulin secretion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
release of sequestered calcium ion into cytosol
protein homooligomerization
protein heterooligomerization
response to calcium ion
long-term synaptic potentiation
calcium ion transport into cytosol
cellular response to cAMP
regulation of cardiac conduction
transport
ion transport
calcium ion transport
transmembrane transport
calcium ion transmembrane transport
