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产品信息
PA5-57374
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642835
产品详细信息
Immunogen sequence: IFGESGDEEE EEFTGFNQED LEEEKGETQV KEAEDSDSDD NIKRGKHMDF LSDFEMMLQR KKSMSGKRRR NRDGGTFISD ADDVVSAMIV KMNEAA
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
靶标信息
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: interacts with Spt6; IWS1 homolog; IWS1-like protein; Protein IWS1 homolog
基因别名: IWS1; IWS1L
UniProt ID: (Human) Q96ST2
Entrez Gene ID: (Human) 55677
