Invitrogen

IYD Polyclonal Antibody

IYD Antibody in Immunocytochemistry (ICC/IF)

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IYD Antibody (PA5-63757) in ICC/IF

Immunofluorescent staining of IYD in human cell line CACO-2 using an IYD Polyclonal Antibody (Product # PA5-63757) shows localization to plasma membrane.

IYD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IYD Antibody in Immunohistochemistry (IHC)

Product Image Gallery

IYD Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of IYD demonstrates antibody specificity. Immunohistochemical analysis of IYD using anti-IYD Polyclonal Antibody (Product # PA5-63757), shows significant staining of IYD in human thyroid gland and shows minimal or weak staining in human cerebral cortex tissues. The relative expression levels of IYD within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-63757

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:500-1:1,000

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human IYD. Recombinant protein control fragment (Product #RP-101082).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2642837

产品详细信息

Immunogen sequence: ADRSMEKKKG EPRTRAEARP WVDEDLKDSS DLHQAEEDAD EWQESEENVE HIPFSHNHYP EK

Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 65%.

靶标信息

This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Salivary ATP13A2 is a potential marker of therapy-induced motor complications and is expressed by inclusions in submandibulary glands in Parkinson ´s disease.

Clinical parkinsonism & related disorders

Fernández-Espejo E,Gavito AL,Suárez J,Tolosa E,Vilas D,Aldecoa I,Berenguer J,Córdoba-Fernández A,Damas-Hermoso F,Rodríguez de Fonseca F

PA5-63757 was used in Immunohistochemistry to show that this is the first description of ATP13A2-positive inclusions outside the nervous system.

Mon Sep 12 00:00:00 UTC 2022

Salivary ATP13A2 is a potential marker of therapy-induced motor complications and is expressed by inclusions in submandibulary glands in Parkinson ´s disease.

Clinical parkinsonism & related disorders

Fernández-Espejo E,Gavito AL,Suárez J,Tolosa E,Vilas D,Aldecoa I,Berenguer J,Córdoba-Fernández A,Damas-Hermoso F,Rodríguez de Fonseca F

PA5-63757 was used in Immunohistochemistry to show that this is the first description of ATP13A2-positive inclusions outside the nervous system.

Mon Sep 12 00:00:00 UTC 2022

Native α-Synuclein, 3-Nitrotyrosine Proteins, and Patterns of Nitro-α-Synuclein-Immunoreactive Inclusions in Saliva and Submandibulary Gland in Parkinson's Disease.

Antioxidants (Basel, Switzerland)

Fernández-Espejo E,Rodríguez de Fonseca F,Suárez J,Tolosa E,Vilas D,Aldecoa I,Berenguer J,Damas-Hermoso F

PA5-63757 was used in Immunohistochemistry to study the pathological role of native αSyn, 3-NT-αSyn, and 3-NT-proteins in the saliva and submandibulary glands of patients with idiopathic Parkinson''s disease.