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Iduronate 2 Sulfatase Antibody (PA5-46990) in WB
Western blot analysis of Iduronate 2 Sulfatase in human peripheral blood mononuclear cells (PBMCs). Samples were incubated in Iduronate 2 Sulfatase polyclonal antibody (Product # PA5-46990) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Goat IgG secondary antibody. A specific band was detected for Iduronate 2‚Sulfatase/IDS at approximately 42 kDa (as indicated). This experiment was conducted ... View More
产品信息
PA5-46990
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human IDS Ser26-Pro550
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609190
产品详细信息
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse IDS is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-L-iduronate sulfate sulfatase; Iduronate 2-sulfatase; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; Idursulfase
基因别名: IDS; MPS2; SIDS
UniProt ID: (Human) P22304
Entrez Gene ID: (Human) 3423
