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产品信息
PA5-90575
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 728-1081 of human IPO4 (NP_0789343)
偶联物
形式
Liquid
浓度
0.94 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806126
产品详细信息
Immunogen sequence: LHKACQSCPS EPNTAALQAA LARVVPSYMQ AVNRERERQV VMAVLEALTG VLRSCGTLTL KPPGRLAELC GVLKAVLQRK TACQDTDEEE EEEDDDQAEY DAMLLEHAGE AIPALAAAAG GDSFAPFFAG FLPLLVCKTK QGCTVAEKSF AVGTLAETIQ GLGAASAQFV SRLLPVLLST AQEADPEVRS NAIFGMGVLA EHGGHPAQEH FPKLLGLLFP LLARERHDRV RDNICGALAR LLMASPTRKP EPQVLAALLH ALPLKEDLEE WVTIGRLFSF LYQSSPDQVI DVAPELLRIC SLILADNKIP PDTKAALLLL LTFLAKQHTD SFQAALGSLP VDKAQELQAV LGLS; Positive Samples: HeLa, SH-SY5Y, A-549, HepG2, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Nucleus
靶标信息
Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Imp4; Imp4a; Imp4b; importin 4a; Importin-4; Importin-4a; Importin-4b; Ran-binding protein 4; RanBP4
基因别名: 8430408O15Rik; AA409693; Imp4; Imp4a; IMP4B; IPO4; RANBP4
UniProt ID: (Human) Q8TEX9, (Mouse) Q8VI75
Entrez Gene ID: (Human) 79711, (Rat) 290228, (Mouse) 75751
protein import into nucleus, docking
protein import into nucleus, translocation
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
protein transport
intracellular protein transport
transport
ribosome biogenesis
