NeoBiotechnologies

Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Monoclonal Antibody (SMARCB1/3984)

Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Antibody (6598-MSM4-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human testis stained with INI-1 Mouse Monoclonal Antibody (SMARCB1/3984) at 2 µg/mL. Inset: PBS instead of primary antibody, secondary negative control.

Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Antibody in Peptide array (ARRAY)

Integrase interactor 1 (INI-1)/SNF5/SMARCB1 Antibody in Immunoelectrophoresis (IE)

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产品信息

6598-MSM4-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

肽阵列 (Array)

Assay-dependent

免疫电泳 (IE)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

SMARCB1/3984

抗原

Recombinant fragment (around aa 65-184) of human SMARCB1 protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: Human brain, astrocytoma or kidney. Cellular Localization: Nucleus.

Specificity Comments: The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.

靶标信息

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: BAF47; BRG1-associated factor 47; BRG1-associated factor 47 (BAF47); hSNF5; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; protein phosphatase 1, regulatory subunit 144; SNF5 homolog; Sucrose nonfermenting yeast homolog like 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI/SNF-related matrix-associated protein; SWI10; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4

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基因别名: BAF47; CSS3; hSNFS; INI1; MRD15; PPP1R144; RDT; RTPS1; Sfh1p; SMARCB1; SNF5; SNF5L1; Snr1; SWNTS1

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UniProt ID: (Human) Q12824

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Entrez Gene ID: (Human) 6598

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