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产品信息
MA5-49039
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
BV12
抗原
H5V endothelial cells
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein G
保存液
PBS with 1% BSA
内含物
0.02% sodium azide
保存条件
4° C, store in dark
运输条件
Wet ice
RRID
AB_3093284
产品详细信息
The monoclonal antibody BV12 recognizes junctional adhesion molecule-A (JAM-A), also known as JAM-1 and the mouse platelet F11-Receptor (F11R), is a cell adhesion molecule (CAM).
靶标信息
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: BV11 antigen; CD321; F11 R; F11 receptor/F11R; JAM-1; JAM-A; junction cell adhesion molecule A; junction cell adhesion molecule1; Junctional adhesion molecule 1; Junctional adhesion molecule A
基因别名: 9130004G24; AA638916; ESTM33; F11r; JAM; JAM-1; JAM-A; Jam1; Jcam; Jcam1; Ly106
UniProt ID: (Mouse) O88792
Entrez Gene ID: (Mouse) 16456
cell adhesion
viral process
epithelial cell differentiation
actomyosin structure organization
negative regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of blood pressure
intestinal absorption
establishment of protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of membrane permeability
regulation of actin cytoskeleton reorganization
