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JARID1C Antibody (PA5-115462) in IHC (P)
Immunohistochemistry analysis of JARID1C in mouse colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115462) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115462
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KDM5C(Accession P41229), corresponding to amino acid residues L1440-E1490.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900098
Product Specific Information
Antibody detects endogenous levels of total KDM5C / Jarid1C / SMCX.
Target Information
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(4) demethylase 5C; Histone demethylase JARID1C; JmjC domain-containing protein SMCX; jumonji, AT rich interactive domain 1C (Rbp2 like); Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; lysine (K)-specific demethylase 5C; Lysine-specific demethylase 5C; Protein SmcX; Protein Xe169; sele; selected mouse cDNA on the X; Smcx homolog, X chromosome; Smcy homolog, X-linked
Gene Aliases: D930009K15Rik; DXS1272E; JARID1C; KDM5C; Kiaa0234; mKIAA0234; MRX13; MRXJ; MRXSCJ; MRXSJ; RGD1560601; SMCX; XE169
UniProt ID: (Human) P41229, (Mouse) P41230
Entrez Gene ID: (Human) 8242, (Mouse) 20591, (Rat) 317432
DNA binding
zinc ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
histone demethylase activity
histone demethylase activity (H3-K4 specific)
sulfonate dioxygenase activity
RNA polymerase II transcription factor binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
identical protein binding
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
molecular_function
histone modifying enzyme
transcription, DNA-templated
histone H3-K4 demethylation
negative regulation of transcription, DNA-templated
rhythmic process
oxidation-reduction process
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
chromatin modification
regulation of circadian rhythm
response to toxic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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