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产品信息
PA5-27224
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 112 and 510 of Human JIP-1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2544700
产品详细信息
Recommended positive controls: HepG2.
Predicted reactivity: Mouse (94%), Rat (94%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-Jun-amino-terminal kinase-interacting protein 1; IB-1; Islet-brain 1; Islet-brain-1; JIP-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; mitogen activated protein kinase 8 interacting protein 1; Mitogen-activated protein kinase 8-interacting protein 1; PRKM8 interacting protein; protein kinase, mitogen-activated 8 interacting protein
基因别名: IB1; JIP-1; JIP1; Mapk8ip; MAPK8IP1; mjip-2a; PRKM8IP; Skip
UniProt ID: (Human) Q9UQF2, (Mouse) Q9WVI9
Entrez Gene ID: (Human) 9479, (Mouse) 19099
regulation of transcription, DNA-templated
JUN phosphorylation
positive regulation of signal transduction
vesicle-mediated transport
negative regulation of JUN kinase activity
regulation of JNK cascade
negative regulation of intrinsic apoptotic signaling pathway
signal transduction
negative regulation of apoptotic process
negative regulation of JNK cascade
