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产品信息
PA5-29245
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 529 and 804 of Human JIP2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546721
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain.
Predicted reactivity: Mouse (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-Jun-amino-terminal kinase-interacting protein 2; homologous to mouse JIP-1; IB 2; IB-2; Islet brain 2; islet-brain 2; Islet-brain-2; JIP 2; JIP-2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; mitogen activated protein kinase 8 interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2
基因别名: 3230402N03Rik; AI847694; AW049958; IB-2; IB2; JIP2; MAPK8IP2; PRKM8IPL; R75148
UniProt ID: (Human) Q13387, (Mouse) Q9ERE9
Entrez Gene ID: (Human) 23542, (Mouse) 60597
behavioral fear response
signal complex assembly
JNK cascade
mating behavior
regulation of receptor activity
positive regulation of stress-activated MAPK cascade
social behavior
regulation of JNK cascade
nonassociative learning
dendrite morphogenesis
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
MAPK cascade
positive regulation of protein kinase activity
