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产品信息
PA5-57057
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642847
产品详细信息
Immunogen sequence: FSLSTFHSLS PPGCRPPQDI SLEEFDDEDL SEITDDCGLG LSYDSDHCEK DSLSLGRSEQ PHPICSFQDD FQEFEM
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
靶标信息
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
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生物信息学
蛋白别名: C-Jun-amino-terminal kinase-interacting protein 2; homologous to mouse JIP-1; IB 2; IB-2; Islet brain 2; islet-brain 2; Islet-brain-2; JIP 2; JIP-2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2
基因别名: IB-2; IB2; JIP2; MAPK8IP2; PRKM8IPL
UniProt ID: (Human) Q13387
Entrez Gene ID: (Human) 23542
behavioral fear response
signal complex assembly
JNK cascade
mating behavior
regulation of receptor activity
positive regulation of stress-activated MAPK cascade
social behavior
regulation of JNK cascade
nonassociative learning
dendrite morphogenesis
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
