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产品信息
PA5-142058
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence MEIQMDEGGGVV-C (aa 2-13).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2932720
产品详细信息
Additional Information: This antibody is expected to recognise both reported Human isoforms of this protein (as represented by NP_055948.2 and NP_001035529.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
靶标信息
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JSAP1; JUN/SAPK-associated protein 1; mitogen activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; Sunday driver 2
基因别名: BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; Mapk8ip3; mKIAA1066; Syd2
UniProt ID: (Mouse) Q9ESN9
Entrez Gene ID: (Mouse) 30957
in utero embryonic development
JNK cascade
activation of JUN kinase activity
axon guidance
respiratory gaseous exchange
protein localization
post-embryonic development
positive regulation of signal transduction
regulation of gene expression
vesicle-mediated transport
forebrain development
positive regulation of JUN kinase activity
positive regulation of neuron differentiation
regulation of JNK cascade
lung alveolus development
lung morphogenesis
