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产品信息
MA5-15724
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2E1
抗原
Purified recombinant fragment of human KDM3A expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10983826
产品详细信息
MA5-15724 targets KDM3A in indirect ELISA, IF and WB applications and shows reactivity with Human samples.
The MA5-15724 immunogen is purified recombinant fragment of human KDM3A expressed in E. Coli.
MA5-15724 detects KDM3A which has a predicted molecular weight of approximately 147kDa.
靶标信息
JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H3]-dimethyl-L-lysine(9) demethylase 3A; DKFZp686A24246; DKFZp686P07111; JmjC domain-containing histone demethylation protein 2A; jumonji C domain-containing histone demethylase 2A; Jumonji domain-containing protein 1A; lysine (K)-specific demethylase 3A; Lysine-specific demethylase 3A; testis-specific protein A
基因别名: JHDM2A; JHMD2A; JMJD1; JMJD1A; KDM3A; KIAA0742; TSGA
UniProt ID: (Human) Q9Y4C1
Entrez Gene ID: (Human) 55818
response to hypoxia
transcription, DNA-templated
spermatid nucleus elongation
male gonad development
hormone-mediated signaling pathway
androgen receptor signaling pathway
histone H3-K9 demethylation
histone H3-K9 dimethylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
formaldehyde biosynthetic process
negative regulation of histone H3-K9 methylation
oxidation-reduction process
regulation of stem cell population maintenance
regulation of stem cell differentiation
