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产品信息
PA5-23065
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide made to an internal region of the human JMJD2C protein (within residues 450-600).
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152049
产品详细信息
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
靶标信息
Jumonji domain-containing protein 2C (JMJD2C)/ Lysine-specific demethylase 4C (KDM4C) is a histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3; thereby, playing a central role in histone code. KDM4C does not demethylate histone H3 'Lys-4', H3 'Lys-27', or H4 'Lys-20'. It demethylates trimethylated H3 "Lys-9' and H3 "Lys-36' residues. There is no activity on mono- or dimethylated residues. Demethylation of Lys residues generates formaldehyde and succinate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(9) demethylase 4C; bA146B14.1; GASC-1 protein; gene amplified in squamous cell carcinoma 1; Gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C; jumonji domain containing 2C; Jumonji domain-containing protein 2C; lysine (K)-specific demethylase 4C; Lysine-specific demethylase 4C; RP11-169L18.1; tudor domain containing 14C
基因别名: 2410141F18Rik; AA517467; GASC1; JHDM3C; JMJD2C; KDM4C; KIAA0780; TDRD14C
UniProt ID: (Human) Q9H3R0, (Mouse) Q8VCD7
Entrez Gene ID: (Human) 23081, (Mouse) 76804
zinc ion binding
enzyme binding
histone demethylase activity
histone demethylase activity (H3-K9 specific)
androgen receptor binding
dioxygenase activity
sulfonate dioxygenase activity
chromatin binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
blastocyst formation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
regulation of gene expression
positive regulation of gene expression
chromatin modification
histone demethylation
histone H3-K9 demethylation
positive regulation of neuron differentiation
oxidation-reduction process
