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JNK2 beta Antibody (PA5-142861) in IHC (P)
Immunohistochemistry analysis of JNK2 beta in human kidney. Samples were incubated with JNK2 beta polyclonal antibody (Product # PA5-142861) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
产品信息
PA5-142861
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-EMVLHKVLFPGRDY.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933504
产品详细信息
Additional Information: This antibody is expected to recognize isoforms beta1 and beta 2 (NP_620708.1; NP_620709.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
靶标信息
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]. MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK-55; JNK/SAPK alpha; Jun kinase; MAP kinase 9; MAPK 9; mitogen activated protein kinase 9; Mitogen-activated protein kinase 9; protein kinase, mitogen-activated 9; SAPK1a; Stress-activated protein kinase 1a; Stress-activated protein kinase JNK2
基因别名: AI851083; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; MAPK9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1A
UniProt ID: (Human) P45984, (Mouse) Q9WTU6
Entrez Gene ID: (Human) 5601, (Mouse) 26420
JUN kinase activity
protein binding
ATP binding
transcription factor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
mitogen-activated protein kinase kinase kinase binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
release of cytochrome c from mitochondria
positive regulation of protein phosphorylation
protein phosphorylation
protein targeting to mitochondrion
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to stress
JNK cascade
JUN phosphorylation
central nervous system development
response to mechanical stimulus
response to toxic substance
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of cell morphogenesis involved in differentiation
response to amine
neuron projection development
positive regulation of prostaglandin biosynthetic process
regulation of protein ubiquitination
positive regulation of prostaglandin secretion
positive regulation of chemokine production
cellular response to UV
Fc-epsilon receptor signaling pathway
response to drug
regulation of circadian rhythm
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription, DNA-templated
regulation of JNK cascade
response to cadmium ion
rhythmic process
regulation of sequence-specific DNA binding transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
positive regulation of podosome assembly
positive regulation of apoptotic signaling pathway
phosphorylation
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
