Product References
Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy.
Acta pharmacologica Sinica
Ji XY,Zheng D,Ni R,Wang JX,Shao JQ,Vue Z,Hinton A,Song LS,Fan GC,Chakrabarti S,Su ZL,Peng TQ
40-5300 was used in Western Blot to investigate whether sustained over-expression of calpain-2 had any adverse effects on the heart and the underlying mechanisms.
Tue Nov 01 00:00:00 UTC 2022
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy.
The Biochemical journal
Wang J,Ciampa G,Zheng D,Shi Q,Chen B,Abel ED,Peng T,Hall DD,Song LS
Published figure using JPH2 polyclonal antibody (Product # 40-5300) in Western Blot
Fri Oct 15 00:00:00 UTC 2021
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart.
NPJ aging and mechanisms of disease
Lyu Y,Verma VK,Lee Y,Taleb I,Badolia R,Shankar TS,Kyriakopoulos CP,Selzman CH,Caine W,Alharethi R,Navankasattusas S,Seidel T,Drakos SG,Sachse FB
40-5300 was used in Western Blot to indicate that targeting sarcolemmal association of JPH2 might ameliorate age-associated deficiencies of heart function.
Fri May 28 00:00:00 UTC 2021
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart.
NPJ aging and mechanisms of disease
Lyu Y,Verma VK,Lee Y,Taleb I,Badolia R,Shankar TS,Kyriakopoulos CP,Selzman CH,Caine W,Alharethi R,Navankasattusas S,Seidel T,Drakos SG,Sachse FB
40-5300 was used in Western Blot to indicate that targeting sarcolemmal association of JPH2 might ameliorate age-associated deficiencies of heart function.
Fri May 28 00:00:00 UTC 2021
Severe T-System Remodeling in Pediatric Viral Myocarditis.
Frontiers in cardiovascular medicine
Fiegle DJ,Schöber M,Dittrich S,Cesnjevar R,Klingel K,Volk T,Alkassar M,Seidel T
40-5300 was used in Immunocytochemistry to investigate the t-system in pediatric viral myocarditis.
Sat Feb 06 00:00:00 UTC 2021
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Cell reports
Feyen DAM,McKeithan WL,Bruyneel AAN,Spiering S,Hörmann L,Ulmer B,Zhang H,Briganti F,Schweizer M,Hegyi B,Liao Z,Pölönen RP,Ginsburg KS,Lam CK,Serrano R,Wahlquist C,Kreymerman A,Vu M,Amatya PL,Behrens CS,Ranjbarvaziri S,Maas RGC,Greenhaw M,Bernstein D,Wu JC,Bers DM,Eschenhagen T,Metallo CM,Mercola M
40-5300 was used in Western Blotting to describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs.
Tue Jul 21 00:00:00 UTC 2020
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Cell reports
Feyen DAM,McKeithan WL,Bruyneel AAN,Spiering S,Hörmann L,Ulmer B,Zhang H,Briganti F,Schweizer M,Hegyi B,Liao Z,Pölönen RP,Ginsburg KS,Lam CK,Serrano R,Wahlquist C,Kreymerman A,Vu M,Amatya PL,Behrens CS,Ranjbarvaziri S,Maas RGC,Greenhaw M,Bernstein D,Wu JC,Bers DM,Eschenhagen T,Metallo CM,Mercola M
40-5300 was used in Western Blotting to describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs.
Tue Jul 21 00:00:00 UTC 2020
Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility.
Proceedings of the National Academy of Sciences of the United States of America
Pritchard HAT,Griffin CS,Yamasaki E,Thakore P,Lane C,Greenstein AS,Earley S
40-5300 was used in Immunocytochemistry to conclude that JPH2 maintains functional coupling between RyR2s and BK channels and is critically important for cerebral arterial function.
Tue Oct 22 00:00:00 UTC 2019
Cardiac-specific overexpression of caveolin-3 preserves t-tubular ICa during heart failure in mice.
Experimental physiology
Kong CHT,Bryant SM,Watson JJ,Roth DM,Patel HH,Cannell MB,James AF,Orchard CH
40-5300 was used in Western Blotting to study the cellular basis of the protection conferred on the heart by overexpression of caveolin-3 against many of the features of heart failure normally observed in vivo.
Wed May 01 00:00:00 UTC 2019
Cardiac-specific overexpression of caveolin-3 preserves t-tubular ICa during heart failure in mice.
Experimental physiology
Kong CHT,Bryant SM,Watson JJ,Roth DM,Patel HH,Cannell MB,James AF,Orchard CH
40-5300 was used in Western Blotting to study the cellular basis of the protection conferred on the heart by overexpression of caveolin-3 against many of the features of heart failure normally observed in vivo.
Wed May 01 00:00:00 UTC 2019
Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular ICa density in mouse ventricular myocytes.
American journal of physiology. Heart and circulatory physiology
Bryant SM,Kong CHT,Watson JJ,Gadeberg HC,Roth DM,Patel HH,Cannell MB,James AF,Orchard CH
40-5300 was used in Western Blotting to study the structure and function of myocytes isolated from Cav-3 knockouts.
Thu Nov 01 00:00:00 UTC 2018
Caveolin 3-dependent loss of t-tubular ICa during hypertrophy and heart failure in mice.
Experimental physiology
Bryant SM,Kong CHT,Watson JJ,Gadeberg HC,James AF,Cannell MB,Orchard CH
Published figure using JPH2 polyclonal antibody (Product # 40-5300) in Western Blot
Tue May 01 00:00:00 UTC 2018
Caveolin 3-dependent loss of t-tubular ICa during hypertrophy and heart failure in mice.
Experimental physiology
Bryant SM,Kong CHT,Watson JJ,Gadeberg HC,James AF,Cannell MB,Orchard CH
Published figure using JPH2 polyclonal antibody (Product # 40-5300) in Western Blot
Tue May 01 00:00:00 UTC 2018
Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
Science advances
Hu LR,Ackermann MA,Hecker PA,Prosser BL,King B,O'Connell KA,Grogan A,Meyer LC,Berndsen CE,Wright NT,Jonathan Lederer W,Kontrogianni-Konstantopoulos A
40-5300 was used in Western Blotting to postulate that enhanced binding between mutant obscurins and phospholamban leads to SERCA2 disinhibition, which may underlie the observed pathological alterations.
Thu Jun 01 00:00:00 UTC 2017
Correlative Single-Molecule Localization Microscopy and Confocal Microscopy.
Methods in molecular biology (Clifton, N.J.)
Soeller C,Hou Y,Jayasinghe ID,Baddeley D,Crossman D
40-5300 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to describe a procedure to achieve this aim by correlatively imaging human cardiac tissue first at the nanoscale with direct stochastic optical reconstruction microscopy (dSTORM) and then at the diffraction limit with conventional confocal microscopy.
Mon May 14 00:00:00 UTC 2018
Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.
Journal of cell science
Munro ML,Jayasinghe I,Wang Q,Quick A,Wang W,Baddeley D,Wehrens XH,Soeller C
405300 was used in immunocytochemistry and immunohistochemistry - frozen section to explore the role of junctophilin-2 in the ventricular muscle cells of the heart
Thu Dec 01 00:00:00 UTC 2016
Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.
Journal of cell science
Munro ML,Jayasinghe I,Wang Q,Quick A,Wang W,Baddeley D,Wehrens XH,Soeller C
405300 was used in immunocytochemistry and immunohistochemistry - frozen section to explore the role of junctophilin-2 in the ventricular muscle cells of the heart
Thu Dec 01 00:00:00 UTC 2016
Observation of the molecular organization of calcium release sites in fast- and slow-twitch skeletal muscle with nanoscale imaging.
Journal of the Royal Society, Interface
Jayasinghe ID,Munro M,Baddeley D,Launikonis BS,Soeller C
Published figure using JPH2 polyclonal antibody (Product # 40-5300) in Immunofluorescence
Mon Oct 06 00:00:00 UTC 2014
Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.
The Journal of physiology
Murphy RM,Dutka TL,Horvath D,Bell JR,Delbridge LM,Lamb GD
40-5300 was used in western blot to study junctophilin proteolysis in skeletal muscle.
Fri Feb 01 00:00:00 UTC 2013
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction.
Circulation research
Wagner E,Lauterbach MA,Kohl T,Westphal V,Williams GS,Steinbrecher JH,Streich JH,Korff B,Tuan HT,Hagen B,Luther S,Hasenfuss G,Parlitz U,Jafri MS,Hell SW,Lederer WJ,Lehnart SE
40-5300 was used in Immunocytochemistry-immunoflourescence to study how transverse tubules are progressively remodelled during the development of heart failure, causing early Ca(2+) release unit dysfunction.
Fri Aug 03 00:00:00 UTC 2012
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction.
Circulation research
Wagner E,Lauterbach MA,Kohl T,Westphal V,Williams GS,Steinbrecher JH,Streich JH,Korff B,Tuan HT,Hagen B,Luther S,Hasenfuss G,Parlitz U,Jafri MS,Hell SW,Lederer WJ,Lehnart SE
40-5300 was used in Immunocytochemistry-immunoflourescence to study how transverse tubules are progressively remodelled during the development of heart failure, causing early Ca(2+) release unit dysfunction.
Fri Aug 03 00:00:00 UTC 2012
Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.
The Journal of biological chemistry
Golini L,Chouabe C,Berthier C,Cusimano V,Fornaro M,Bonvallet R,Formoso L,Giacomello E,Jacquemond V,Sorrentino V
Fri Dec 23 00:00:00 UTC 2011
Junctophilin damage contributes to early strength deficits and EC coupling failure after eccentric contractions.
American journal of physiology. Cell physiology
Corona BT,Balog EM,Doyle JA,Rupp JC,Luke RC,Ingalls CP
40-5300 was used in Western Blotting to indicate that Junctophilin damage plays a role in early force deficits due to excitation-contraction coupling failure following the performance of eccentric contractions.
Mon Feb 01 00:00:00 UTC 2010
