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产品信息
PA5-65999
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2663306
产品详细信息
Immunogen sequence: APLGMMTGLDH YIERIQKLLA EQQTLLAENY SELAEAFGEP HSQMGSLNSQ LISTLSSINS VMKSASTEEL RNPDFQKTSL GKITGNYLGY TCKCGGLQSG SPLSSQTSQP EQEVGTSEGK PISSLDAFPT QEGTLSPVNL TDDQ
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 79%.
靶标信息
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1
基因别名: ANKRD15; CPSQ2; KANK; KANK1; KIAA0172
UniProt ID: (Human) Q14678
Entrez Gene ID: (Human) 23189
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of neuron projection development
positive regulation of Wnt signaling pathway
negative regulation of cell migration
negative regulation of actin filament polymerization
negative regulation of Rho protein signal transduction
positive regulation of catenin import into nucleus
negative regulation of insulin receptor signaling pathway
positive regulation of wound healing
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
regulation of establishment of cell polarity
negative regulation of lamellipodium morphogenesis
