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产品信息
OSP00071W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the cytoplasmic domain of human KCNE1 (Potassium voltage-gated channel subfamily E member 1) conjugated to an immunogenic carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: KCNE1.
靶标信息
Kcne1 is a member of Voltage-gated potassium (Kv) channels that represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of Kv channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kcne1 gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. Functionally, Kcne1 is a potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Kcne1 also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cardiac delayed rectifier potassium channel protein; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; JLNS 2; KCNE 1; KCNE1 (IsK); LQT 5; MGC33114; Minimal potassium channel; MinK; potassium channel, voltage gated subfamily E regulatory beta subunit 1; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit
基因别名: ISK; JLNS; JLNS2; KCNE1; LQT2/5; LQT5; MinK
UniProt ID: (Human) P15382
Entrez Gene ID: (Human) 3753
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
protein binding
potassium channel regulator activity
telethonin binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel
protein N-linked glycosylation
protein O-linked glycosylation
sensory perception of sound
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac conduction
cellular response to cAMP
potassium ion export
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
membrane repolarization
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
negative regulation of protein targeting to membrane
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
regulation of delayed rectifier potassium channel activity
negative regulation of delayed rectifier potassium channel activity
