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KCNE1 (IsK) Antibody (APC-163-200UL) in WB
Western blot analysis of rat kidney (lanes 1 and 4), rat heart (lanes 2 and 5) and mouse kidney (lanes 3 and 6) membranes: - 1-3. Anti-KCNE1 (IsK) Antibody (#APC-163), (1:200).4-6. Anti-KCNE1 (IsK) Antibody , preincubated with KCNE1/IsK Blocking Peptide (#BLP-PC163).
产品信息
APC-163-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RSKKLEHSHDPFN, corresponding to amino acid residues 68-80 of rat KCNE1, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Kcne1 is a member of Voltage-gated potassium (Kv) channels that represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of Kv channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kcne1 gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. Functionally, Kcne1 is a potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Kcne1 also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; JLNS 2; KCNE 1; KCNE1 (IsK); LQT 5; MGC33114; Minimal potassium channel; MinK; mISK; potassium (K+) channel protein, slowly activating (Isk); potassium voltage-gated channel Shaw-related subfamily member 1; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1
基因别名: Isk; Kcne1; m; MinK; nmf190
UniProt ID: (Mouse) P23299, (Rat) P15383
Entrez Gene ID: (Mouse) 16509, (Rat) 25471
voltage-gated ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
potassium channel regulator activity
ion channel binding
protein heterodimerization activity
protein binding
telethonin binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel
epithelial cell maturation
transport
ion transport
potassium ion transport
regulation of ion transmembrane transport
heart contraction
regulation of membrane repolarization
cellular response to acidic pH
potassium ion transmembrane transport
membrane repolarization during action potential
regulation of heart rate by cardiac conduction
negative regulation of protein targeting to membrane
regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
positive regulation of voltage-gated calcium channel activity
negative regulation of delayed rectifier potassium channel activity
negative regulation of voltage-gated potassium channel activity
protein N-linked glycosylation
protein O-linked glycosylation
male gonad development
regulation of ventricular cardiac muscle cell membrane repolarization
cellular response to cAMP
potassium ion export
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of delayed rectifier potassium channel activity
