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KCNE2 Antibody (PA5-117163) in WB
Western blot analysis of KCNE2 in extracts of U-251MG cells. Samples were incubated with KCNE2 Polyclonal antibody (Product # PA5-117163) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-117163
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE2 (NP_7519511)
偶联物
形式
Liquid
浓度
0.58 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901793
产品详细信息
Positive Samples: U-251MG
Immunogen sequence: MSTLSNFTQT LEDVFRRIFI TYMDNWRQNT TAEQEALQAK VDAENFYYVI LYLMVMIGMF SFIIVAILVS TVKSKRREHS NDPYHQYIVE DWQEKYKSQI
靶标信息
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac voltage-gated potassium channel accessory subunit 2; CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IL-10R2; minimum potassium ion channel related peptide 1; Minimum potassium ion channel-related peptide 1; MinK-related peptide 1; minK-related peptide-1; MiRP1; Potassium channel subunit beta MiRP1; potassium channel subunit, MiRP1; potassium channel, voltage gated subfamily E regulatory beta subunit 2; Potassium voltage-gated channel subfamily E member 2; potassium voltage-gated channel, Isk-related family, member 2; voltage-gated K+ channel subunit MIRP1
基因别名: 2200002I16Rik; ATFB4; AW048273; KCNE2; LQT5; LQT6; MIRP1
UniProt ID: (Human) Q9Y6J6, (Mouse) Q9D808
Entrez Gene ID: (Human) 9992, (Mouse) 246133
inward rectifier potassium channel activity
delayed rectifier potassium channel activity
protein binding
potassium channel regulator activity
protein homodimerization activity
ion channel binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
voltage-gated potassium channel activity
potassium channel activity
voltage-gated ion channel
aging
potassium ion import
cellular response to drug
tongue development
regulation of membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac conduction
potassium ion export
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
membrane repolarization
membrane repolarization during action potential
regulation of heart rate by cardiac conduction
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
positive regulation of voltage-gated calcium channel activity
positive regulation of proteasomal protein catabolic process
regulation of inward rectifier potassium channel activity
regulation of cyclic nucleotide-gated ion channel activity
regulation of delayed rectifier potassium channel activity
negative regulation of delayed rectifier potassium channel activity
transport
ion transport
potassium ion transport
cellular protein localization
regulation of ion transmembrane transport
membrane repolarization during cardiac muscle cell action potential
negative regulation of voltage-gated potassium channel activity
