Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-77042
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human KCNH1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720769
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH1 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH1 is activated at the onset of myoblast differentiation. KCNH1 is highly expressed in brain and in myoblasts. Overexpression of KCNH1 may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of KCNH1 results in two transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: EAG channel 1; EAG1; ether a go-go; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; potassium channel, voltage gated eag related subfamily H, member 1; Potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; Voltage-gated delayed rectifier potassium channel KCNH1; Voltage-gated potassium channel subunit Kv10.1
基因别名: EAG; EAG1; h-eag; hEAG1; KCNH1; Kv10.1; M-eag; TMBTS; ZLS1
UniProt ID: (Human) O95259, (Rat) Q63472, (Mouse) Q60603
Entrez Gene ID: (Human) 3756, (Rat) 65198, (Mouse) 16510
phosphorelay sensor kinase activity
delayed rectifier potassium channel activity
protein binding
calmodulin binding
protein kinase binding
cyclic nucleotide binding
identical protein binding
ion channel binding
protein heterodimerization activity
14-3-3 protein binding
voltage-gated potassium channel activity
signal transducer activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
ion channel
phosphorelay signal transduction system
startle response
potassium ion transport
myoblast fusion
signal transduction by protein phosphorylation
regulation of ion transmembrane transport
regulation of cell proliferation
regulation of membrane potential
cellular response to calcium ion
potassium ion transmembrane transport
ion transmembrane transport
transport
ion transport
signal transduction
transmembrane transport
